Alpha 2 (α2) Antiplasmin

Coagulation

---

Description

A screening test for detecting alpha-2-antiplasmin deficiency.

α2-antiplasmin is the most important physiological inhibitor of the fibrinolytically active enzyme plasmin, with which it very quickly forms an irreversible inactive complex.

---

Indications

Reduced α2 antiplasmin activity is found in cases of hyperfibrinolysis that can occur as a complication of disseminated intravascular coagulation (DIC) or in operations on organs with a high content of plasminogen activators. An α2-antiplasmin deficiency may also indicate a synthesis disorder (e.g. in severe liver cell damage). The determination of α2-antiplasmin is also indicated for additional assessment of problematic cases during fibrinolytic therapy.

---

Sample Type

Plasma (Citrate 2.7ml Blue) x 2 or frozen (-80°C) citrated (0.109M) single spun platelet poor plasma, frozen in less than 6 hours from venepuncture.

---

Reference Range

Current adult reference range indicated on the report.

---

Turnaround Time

Within 5 weeks

---

Testing Frequency

As required (usually batched). Please contact the laboratory for urgent requests.

---

External Notes

The accuracy of all coagulation tests is greatly influenced by pre analytical variables. It is essential that sample quality is given the highest of priorities. Samples which fail to meet quality criteria including age of sample, specimen fill (>90%), haemolysed, clotted or activated samples will be rejected and a repeat sample requested.

---

Patient Preparation

No special requirements.

---

References

Kraus M. Alpha 2 antiplasmin. In: Thomas L, ed. Clinical Laboratory Diagnostics. Frankfurt: THBooks Verlagsgesellschaft, 1998: 627-8.
Carpenter SL, Mathew P. Alpha2-antiplasmin and its deficiency: fibrinolysis out of balance. Haemophilia. 2008 Nov;14(6):1250-4.

---

Please note: the above information is subject to change and we endeavour to keep this website up to date wherever necessary.