Clinical Chemistry

Leading edge pathology conducted by a dedicated team of highly trained, skilled and specialised scientists

Clinical Chemistry

Our experienced team provide a wide range of routine and specialist chemistry testing including toxicology.  We provide a specialist service for the assay of a variety of steroid and peptide hormones, biogenic amines, bone markers and trace metals. We provide scientific expertise in support of the national Choriocarcinoma Screening Service. Our Toxicology team provides forensic and non-forensic toxicology services to a significant number of coroners across the UK.

If you would like to know more about how we can help you, please contact us by telephone on 0114 226 7666 or email us at sth.labmed@nhs.net

Department Specific Tests

1, 25 Di-Hydroxy Vitamin D ( Active 1,25 Vitamin D )

11-Deoxycortisol

17a Hydroxyprogesterone

25-Hydroxy Vitamin D (Vitamin D)

5-Hydroxyindole Acetic Acid, 5HIAA (Urine)

5a-Dihydrotestosterone (DHT)

5HIAA (Serum)

7-Dehydrocholesterol (Smith Lemli Opitz Syndrome)

ACTH

Acute Kidney Injury

Acylcarnitine profile

Alanine Transaminase (ALT SGPT)

Albumin

Albumin:creatinine ratio

Alcohol

Aldolase B mutation (Hereditary Fructose Intolerance)

Alkaline Phosphatase

Alkaline Phosphatase Isoenzymes

Alpha Galactosidase (Fabry)

Alpha Glucosidase ( Pompe )

Aluminium

Amino Acids (quantitative) or Branched Chain Amino Acids (isoleucine, alloisoleucine, leucine, valine)

Amiodarone with desethylamiodarone

Amitriptyline and Nortriptyline

Ammonia, NH3

Amylase

Amylase Isoenzymes

Androstenedione

Angiotensin Converting Enzyme (ACE)

Anti-Mullerian Hormone (AMH)

Antidiuretic hormone (Arginine Vasopressin AVP, ADH)

Antiepileptics: Gabapentin; Levetiracetam (Keppra); Oxcarbazepine (Trileptal); Topiramate; Zonisamide

APO E2 Genotyping

Arsenic

Aspartate Aminotransferase (AST, SGOT)

Assays for Gentamicin, Tobramycin, Vancomycin and Teicoplanin

Beryllium

Bicarbonate

Bile Acids (3a-hydroxy bile acids)

Bilirubin (Total, Conjugated (Direct) )

Biotinidase

Blood Gases (ABG)

Bone Alkaline Phosphatase (Bone ALP)

Bupivicaine

Buprenorphine

C-Peptide

C-Reactive Protein (CRP)

Cadmium

Calcitonin (Charing Cross Assay, STH requests)

Calcium

Carbamazepine

Carboxyhaemoglobin / Carbon Monoxide

Carnitine

Carotenoids (alpha-carotene, beta-carotene)

Catecholamines ( Adrenaline, Noradrenaline and Dopamine)

Chloride

Cholestanol

Chromium

Citrate (urine)

Clozapine

Cobalt

Copper

Cortisol

Cortisol and cortisone (salivary)

Cortisol Binding Globulin

Cortisol by LC-MS/MS

Creatine Kinase (CK)

Creatinine

CSF ACE

CSF Bilirubin (Xanthochromia)

CSF Orexin (Hypocretin)

Cyclosporin/Ciclosporin (CYA, CSA)

Cystine (Urine)

Dehydroepiandrosterone Sulphate (DHEAS)

Digoxin

Diuretic screen: Thiazides, Indapamide, Frusemide

Drugs of Abuse Screen: opiates, methadone, EDDP, amphetamines, barbiturates, benzodiazepines, cannabinoids, cocaine metabolites, buprenorphine, norbuprenorphine

Enhanced Liver Fibrosis Test (ELF)

Ethanol

Ethylene Glycol

Everolimus (Votubia)

Faecal alpha-1 antitrypsin

Faecal Reducing Substances

Familial Hypercholesterolaemia (FH) Genetics

Ferritin

Fibroblast Growth Factor 23 (FGF23)

Folate (Serum)

Follicle Stimulating Hormone (FSH)

Free Androgen Index (FAI)

Free T3

Free T4

Galactosaemia screen (Galactose -1- phosphate uridyl transferase)

Galactose-1-phosphate, Galactose-1-phosphate uridyl transferase (quantitative) and Galactokinase

Gamma glutamyl transferase (GGT)

Globulin

Glucose

Glycosaminoglycans (Mucopolysaccharides, MPS)

Growth Hormone

Gut hormones (Gastrin, Vasoactive Intestinal Peptide (VIP), Pancreatic Polypeptide (PP), Glucagon, Somatostatin, Chromogranin A and B)

HFE Haemochromatosis genetics

High sensitivity Troponin T

Holotranscobalamin (Active B12)

Homocysteine and Methionine

Human Chorionic Gonadotropin (HCG)

IGF Binding Protein 3 ( IGFBP3 )

Insulin

Insulin-Like Growth Factor (IGF-1)

Insulin-like growth factor II (IGF-II)

Intermediary Metabolites (Free Fatty Acids, 3-hydroxybutyrate)

Iron, TIBC, Transferrin Saturation, Iron Profile

Karyotyping

Lactate Dehydrogenase (LDH)

Lactic Acid (Lactate)

Lamotrigine

Laxative screen

Lead

Leukocyte Cysteine

Lipase

Lipids (Cholesterol, triglycerides, HDL)

Lipoprotein Electrophoresis

Lipoproteins: lipoprotein (a), apolipoprotein (a) or lipoprotein (X)

Lithium

Liver biopsy for copper or iron quantitation

Luteinising Hormone (LH)

Lyso GB3

Macro Creatine Kinase (Macro CK)

Manganese

Mercury

Metanephrines

Metanephrines (Plasma)

Methanol

Methotrexate

Methylmalonate (urine or plasma)

Mitotane

Mycophenolic acid (MMF)

N-Telopeptide (NTX)

Neonatal Routine Chemistry

Neurotransmitters (CSF) (monoamine metabolites)

Nickel

Oestradiol (E2)

Olanzapine

Organic Acids Profile

Orotic acid

Osmolality

Osteocalcin

Oxalate

Oxysterol (Neimann-Pick type C)

Pancreatic Faecal Elastase-1

Paracetamol

Paraquat and Diquat

Parathyroid Hormone (PTH)

Parathyroid Hormone Related Peptide (PTH rP)

Phenobarbital

Phenylalanine

Phenytoin (Epanutin)

Phosphate

Phytosterols ( inc. sitosterol, campesterol, stigmasterol )

Pituitary polypeptide - alpha subunit

Porphobilinogen (PBG) in Urine: Acute Porphyria

Porphyrin tests: Cutaneous Porphyria

Potassium

Prednisolone

Progesterone

Proinsulin

Prolactin

Protein (CSF)

Protein (urine):- Protein:creatinine ratio (PCR) or 24 hour urine protein

Renal calculi/renal stones

Renin and Aldosterone

Salicylate

Selenium

Serotonin

Sex Hormone Binding Globulin (SHBG)

Sirolimus

Smith Magenis Test

Sodium

Steroid profile (Urine)

Sulphonylurea Screen

Tacrolimus (FK506)

Testosterone

Testosterone by LC-MS/MS

Thallium

Theophylline (Aminophylline)

Thioguanine nucleotides/thiopurine metabolites ( 6TGN & 6MMPN )

Thiopentone/Thiopental

Thiopurine Methyl Transferase (TPMT)

Thyroid Interference Studies

Thyroid Stimulating Hormone (TSH)

Total Procollagen Type-1 N-Terminal Propeptide/Procollagen Extension Peptide (P1NP)

Total Protein

Toxicology / Drug Screen in Suspected Poisoning

Transferrin Glycoforms ( isoelectric focusing )

Trimethylamine and Oxide (Fish Odour Syndrome)

Urea

Uric Acid (Urate)

Urine Free Cortisol (UFC)

Valproate

Very Long Chain Fatty Acids (VLCFA)

Vitamin A

Vitamin B1 (Thiamine)

Vitamin B12 (serum)

Vitamin B2 (Riboflavin)

Vitamin B6 ( Pyridoxine - Pyridoxal phosphate and isomers )

Vitamin C (Plasma Ascorbic acid)

Vitamin E

Vitamin K

White cell or leucocyte cystine - SEE Leukocyte Cysteine

Zinc