Leading edge pathology conducted by a dedicated team of highly trained, skilled and specialised scientists


Coagulation at Sheffield Teaching Hospitals NHS Foundation Trust forms a major part of the Haematology department within the Laboratory Medicine directorate, with a reputation both nationally and internationally for its quality service, repertoire of tests performed and experience both laboratory-based and clinical. With departments based at both the Royal Hallamshire (RHH) and the Northern General Hospitals (NGH) we provide diagnostic and support services to inpatients, outpatients and General Practitioner patients in Sheffield and surrounding areas, and specialist services to national users.

Our service is fully integrated into National and Regional quality assurance schemes. The department is fully accredited with CPA and had its first UKAS inspection in 2016.  The department offers a broad repertoire of tests and services including; extensive Factor assay, thrombophilia and lupus investigations for congenital and acquired disorders of Haemostasis and Thrombosis. 

Specialist coagulation services include investigations of Haemophilia and allied disorders, Thrombophilia, Antiphospholipid antibodies, platelet function and ADAMTS-13.   A rapid and responsive 24/7 ADAMTS13 service for the differential diagnosis of Thrombotic Thrombocytopaenia Purpura (TTP).

The Haemostasis and Thrombosis Centre is designated as a World Health Organisation collaborating centre for the diagnosis and comprehensive care of patients with bleeding and clotting disorders and offers an unparalleled test repertoire In addition the Coagulation Department has close working relationships with UKNEQAS for UKNEQAS Blood Coagulation.

If you would like to know more about how we can help you, please contact us by telephone on 0114 226 7666 or email us at

Department Specific Tests

Activated Partial Thromboplastin Time (APTT)

Activated Protein C Resistance (APCR)

ADAMTS-13 Activity Assay

ADAMTS-13 Antibody Assay

Alpha 2 (α2) Antiplasmin

Anti-beta 2 Glycoprotein 1 Antibody (anti-β2 GP1 Ab)

Anti-Cardiolipin Antibody (ACLA)

Anti-Xa Assay

Antithrombin (ATIII)

Antithrombin Antigen (ATIIIAg)

Chromogenic Factor VIII

Clotting Factor Assays (Factors VIII, IX, II, V, VII, X, XI or XII)

Clotting Screen

Collagen Binding Assay (VWF:CB)


Dilute Russell's Viper Venom Time (DRVVT)

Direct Thrombin Inhibitor Monitoring

Disseminated Intravascular Coagulation (DIC) Screen

Factor V Leiden (FVL)

Factor VII Antigen Assay

Factor VIII Inhibitors (one-stage, chromogenic, porcine)

Factor X Antigen Assay

Factor XIII ( FXIII )

Fibrinogen Antigen

Free Protein S Antigen (FPSAg)

Further investigation of Antithrombin

Heparin Induced Thrombocytopenia ( HIT ) Screen

Heparin Ratio

International Normalised Ratio (INR)

Lupus Anticoagulant Antibody Screen

Non-Specific Clotting Factor Inhibitor

Plasminogen Activity

Platelet Function Testing

Protein C (PC) Chromogenic Assay

Protein C (PC) Clotting Assay

Protein C Antigen (PCAg)

Prothrombin 20210A Allele (PT20210A)

Reptilase Time


Thrombin Time and Protamine Thrombin

Thrombophilia and Lupus Screen

Thrombophilia Screen ( excluding Lupus Screen )

Total Plasma Homocysteine (tHCy)

Two-Stage Clotting Factor VIII:C

von Willebrand Factor (VWF) Multimers

VWF Activity (VWF:Act)

VWF Antigen (VWF:Ag)

VWF:FVIII Binding Assay