Acid Glycoprotein (OROSOMUCOID) / AGP

Immunology

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Description

Acid glycoprotein ( AGP ) is a glycoprotein of 40kDa. It is a �slow' acute phase reactant. Serum levels are increased in inflammation, tissue necrosis and malignancy. Reduced serum concentrations are seen during pregnancy and as a result of treatment with exogenous oestrogens [1,2]. AGP is of little use in the assessment of the acute phase response as it is less sensitive than a combination of CRP and alpha-1 anti-chymotrypsin, although it has been reported to be a marker of activity in inflammatory bowel disease [1,3].

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Indications

Mucosal inflammation.

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Sample Type

2mL Serum ( 6mL Red tube ). Requests from outside Sheffield: Transport at ambient temperature via Royal Mail or Courier.

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Reference Range

Gender | Age range | Acid Glycoprotein Male | 1-50 years | 0.6 - 1.2 g/L Male | 50+ years | 0.8 - 2 g/L Female | 1-50 years | 0.4 - 1.0 g/L Female | 50+ years | 0.8 - 2 g/L Children under 1 year old have a normal range of 0.4 - 1 g/L and do not show variation in gender. Values of up to 2.0 g/L may be considered normal in either sex after the age of 60 years. Reference range established

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Turnaround Time

Within 10 days

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Testing Frequency

2 - 3 times weekly

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References

PRU Handbook of clinical Immunochemistry. 9th Edition. 2007. [Ref 1]Pardi DS, Sandborn WJ. Predicting relapse in patients with inflammatory bowel disease: what is the role of biomarkers? Gut. 2005. 54( 3 ):364-368.Fournier T, Medjoubi-N N and Porquet D. Alpha-1-acid glycoprotein. Biochimica et Biophysica Acta ( BBA ) - Protein Structure and Molecular Enzymology. 2000. 1482( 1-2 ):157-171. [Ref 2]Andre C, et al. Assessment of appropriate laboratory measurements to suppliment the Crohns disease activity index. Gut. 1981. 22:571-574. [Ref 3]

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Please note: the above information is subject to change and we endeavour to keep this website up to date wherever necessary.