Alanine Transaminase (ALT SGPT)

Clinical Chemistry

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Description

Alanine transaminase ( ALT ) is a cytoplasmic enzyme found predominantly in the liver. Lesser amounts are found in skeletal muscle. Guidelines on the investigation of an isolated raised ALT in an asymptomatic adult in primary care can be found at: http://nww.sth.nhs.uk/NHS/LaboratoryMedicine/GP_Guidelines.htm

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Indications

As part of liver function tests.

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Sample Type

Serum ( SST/Gel minimum 5ml ). Avoid haemolysis.

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Reference Range

ALT ( Men ) 0 - 41 U/l ALT ( Women ) 0 - 33 U/l.( Source: Roche )

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Turnaround Time

Within 1 day

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Testing Frequency

Daily

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Patient Preparation

None

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References

Ryder SD. Clinical utility of liver function tests. Proceedings of the ACB National Meeting 2003 p 38-39.Karmen, A., F. Wroblewski, and J. E. LaDue, J. Clin. Inv., 34:126-133 ( 1955 ).Henry, R. J., et al., Amer. J. Clin. Path., 34:381 ( 1960 ).Tietz, N. W.,

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