Glycine Receptor Antibodies

Immunology

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Description

Glycine receptors are required for regulating motor neuron excitabiliy [1]. The presence of glycine receptor antibodies is associated with spinal and brain stem disorders [2] including stiff person syndrome and progressive encephalomyelitis with rigidity and myoclonus (PERM) [1,2].

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Indications

Spinal and brain stem disorders (Stiff person syndrome and PERM).

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Sample Type

2mL Serum (Gel 5mL Yellow tube). Requests from outside Sheffield: Transport at ambient temperature via Royal Mail or Courier.

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Reference Range

Normal = Negative.

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Turnaround Time

Within 4 weeks

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Testing Frequency

As required (send away test).

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References

Alexopoulos H, Akrivou S and Dalakas M. Search for Anti-glycine receptor antibodies in stiff person syndrome. Neurology. 2013, 12:80. [Ref 1].
Carvajal-Gonzalez A, Leite MI, Waters P, et al. Glycine receptor antibodies in PERM and related syndromes: characteristics, clinical features and outcomes. Brain. 2014. 137:2178-2192. [Ref 2].

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