Amyloid A Protein, SAA

Immunology

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Description

Serum amyloid A is an acute phase reactant comprised of a group of polymorphic apolipoproteins, synthesised by hepatocytes and Kupfer Cells [1]. However extrahepatic tissue cellular expression is widely documented. In the plasma it predominately associates with high-density lipoproteins (HDL) [3]. In the acute phase SAA responds in a similar manner to CRP, but may be more sensitive in situations such as renal transplant rejections. SAA is often elevated in malignant diseases and increasing concentrations may be associated with metastatic spread. SAA is a precursor of Amyloid A fibrils, although serum concentrations of SAA are not predictive of fibril formation [1,2].

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Indications

Monitoring of AA Amyloid, inflammation (acute phase marker).

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Sample Type

2mL Serum (Gel 5mL Yellow tube). Requests from outside Sheffield: Transport at ambient temperature via Royal Mail or Courier.

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Reference Range

0 - 10 mg/L.Reference range established

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Turnaround Time

Within 10 days

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Testing Frequency

As required

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References

PRU Handbook of Clinical Immunochemistry. 9th Edition. 2007. [Ref 1]Urieli-Shoval et al. Expression and function of serum amyloid A, a major acute-phase protein, in normal and disease states. Curr Opin Haem. 2000. 7:64-69Yamada T. Serum amyloid A (SAA): a concise review of biology, assay methods and clinical usefulness. Clin Chem Lab Med. 1999. 37(4):381-388Hartmann A, et al. Serum amyloid A protein is a clinically useful indicator of acute renal allograft rejection. Nephrol. Dial. Trans. 1997. 12: 161-166. [Ref 2]Kisilevsky R and Subrahmanyan L. Serum amyloid A changes high density lipoproteins cellular affinity - A clue to serum amyloid A's principle function. Lab Invest. 1992. 66:778-785. [Ref 3]

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See Also

Acid Glycoprotein

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