Beta 2 Glycoprotein 1 Antibodies IgG and IgM (B2GP)

Immunology

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Description

Beta-2-Glycoprotein 1 (also known as apolipoprotein H) is a 50Kda beta-2-globulin found to inhibit the intrinsic coagulation pathway. Beta-2-Glycoprotein 1 is one of the major targets for anti-phospholipid antibodies found in anti-phospholipid syndrome [1]. Anti-B2GP1 antibodies are associated with antiphospholipid syndrome where patients suffer from venous and arterial thrombosis particularly in recurrent unexplained thrombocytopenia, recurrent foetal loss, myocardial infarction and recurrent stroke [2]. These symptoms are often present in cases of systemic lupus erythematosus (SLE) and in many other conditions [2]. The measurement of beta-2-glycoprotein antibodies is of most use in patients suspected of having antiphospholipid syndrome but who have negative results for lupus anticoagulant and anti-cardiolipin antibodies [2]. There is no current evidence that testing for anti-B2GP1 provides any additional diagnostic benefit of anti-cardiolipin antibodies [3].

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Indications

Anti-phospholipid syndrome.

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Sample Type

2mL Serum (Gel 5mL Yellow tube). Requests from outside Sheffield: Transport at ambient temperature via Royal Mail or Courier.

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Reference Range

IgG and IgM B2GP1:
0-10 U/mL Negative.>10.0 U/mL Positive.
Reference range established by manufacturer and verified in house.

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Turnaround Time

Within 5 days

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Testing Frequency

Weekly

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References

Wong RCW, et al. Consensus guidelines on anti-beta 2 glycoprotein I testing and reporting. Pathology. 2008. 40(1):58-63.
Sahin M, et al. Antibodies to beta 2-glycoprotein-I: relation of anticardiolipin antibodies with clinical and laboratory parameters in patients with SLE. Clin Biochem. 2007. 40(8):526-530.
PRU Handbook of Autoimmunity. 4th Edition. 2007.
Miyakis S, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome(APS). J Thrombosis and haemostasis. 2006. 4:295-306.
Marai I, et al. Anticardiolipin and anti-beta-2-glycoprotein I antibodies. Autoimmunity. 2005. 38(1):33-38.
Atsumi T, et al. Research around beta 2-glycoprotein I: a major target for antiphospholipid antibodies. Autoimmunity. 2005. 38(5):377-381.
Guidelines on the investigation and management of The Antiphospholipid Syndrome. British Journal of Haematology. 2000. 109:704-715. [Ref 2]

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Please note: the above information is subject to change and we endeavour to keep this website up to date wherever necessary.