Bilirubin (Total, Conjugated (Direct) )

Clinical Chemistry

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Description

Bilirubin is produced in the normal catabolic pathway that breaks down the haem moiety of haemoglobin. In the liver, bilirubin is conjugated with glucuronic acid by the enzyme UDP-glucuronyltransferase, making it soluble in water. Conjugated bilirubin is referred to as "direct" bilirubin. In an adult, unconjugated hyperbilirubinaemia is usually due to haemolysis, impaired conjugation ( e.g. Gilbert's syndrome ) or drugs. A predominantly conjugated or mixed hyperbilirubinaemia usually indicates hepatobiliary disease. Jaundice becomes clinically apparent at bilirubin concentrations > 50 umol/l. Guidelines on the investigation of an isolated raised bilirubin in an asymptomatic adult in primary care can be found at: http://nww.sth.nhs.uk/NHS/LaboratoryMedicine/GP_Guidelines.htm

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Indications

Usually requested as part of a liver funstion tests profile. In particular, it is indicated in jaundiced patients or if haemolysis is suspected.

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Sample Type

Serum. SST/Gel, minimum 2mL (1mL separated serum). Protect from light.

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Reference Range

Reference ranges are provided on the report. Alternatively, please contact the laboratory for current ranges.

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Turnaround Time

Within 1 day

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Testing Frequency

Daily

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Please note: the above information is subject to change and we endeavour to keep this website up to date wherever necessary.