Ganglioside Antibodies GQ1b (IgG or IgM)

Immunology

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Description

IgG antibodies to ganglioside GQ1b are associated with Miller-Fisher syndrome and specifically those with opthalmoplegia. IgM antibodies to GQ1b are seen in some chronic ataxia neuropathies which share some common clinical features with the Miller-Fisher syndrome.

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Indications

Miller-Fisher Syndrome.

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Sample Type

2mL Serum (Gel 5mL Yellow tube).
Requests from outside Sheffield: transport at ambient temperature via Royal Mail or Courier.

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Reference Range

Normal result = Negative.

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Turnaround Time

Within 10 days

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Testing Frequency

As requested (send away test)

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References

Rinaldi S, Willison HJ. Ganglioside antibodies and neuropathies. Current Opinion in Neurology. 2008. 21(5): 540-546.
Willison HJ, Plomp JJ. Anti-ganglioside antibodies and the pre-synaptic motor nerve terminal. Ann NY Acad Sci. 2008. 1132:114-23.
Lo YL. Clinical and immunological spectrum of the miller fisher syndrome. Muscle and Nerve. 2007. 36(5):615-627.
Chaudhry F, Gee KE, Vaphiades MS. GQ1b antibody testing in Guillain-Barre syndrome and variants. Seminars in Opthalmology. 2006. 21(4):223-227.

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See Also

GM1 (IgG/IgM)
GD1b
GD1a
GT1b (IgG/IgM)

Please note: the above information is subject to change and we endeavour to keep this website up to date wherever necessary.