Cardiac Muscle Antibodies

Immunology

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Description

Cardiac muscle antibodies are described in patients with Dressler's syndrome after myocardial infarction, cardiomyopathy, myocarditis and in patients who have undergone cardiac surgery or have had rheumatic fever. They can be directed towards a number of antigens such as adenine nucleotide translocator protein, cardiac myosin and tropomysin. The presence of antibodies can occur without the Dressler syndrome.

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Indications

Dressler's syndrome, post-MI.

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Sample Type

2mL Serum (Gel 5mL Yellow tube). Requests from outside Sheffield: Transport at ambient temperature via Royal Mail or Courier.

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Reference Range

Normal result = Negative.

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Turnaround Time

Within 10 days

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Testing Frequency

Weekly

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References

Jahns R, Boivin V, Schwarzbach V et al. Pathological autoantibodies in cardiomyopathy. Autoimmunity. 2008. 41(6):454-461. [Ref 1]
Okasaki T, Honjo T. Pathogenic roles of cardiac autoantibodies in dilated cardiomyopathy. Trends Mol Med. 2005. 11(7):322-326. [Ref 2]
Caforio AL, Daliento L, Angelini A et al. Autoimmune myocarditis and dilated cardiomyopathy: focus on cardiac autoantibodies. Lupus. 2005. 14(9):652-655.

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See Also

Skeletal muscle

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