Lymphoproliferative investigation (Peripheral blood lymphocytosis, CLL, Lymphoma)

Haematology

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Description

The lymphoproliferative protocol is performed on patients presenting with a peripheral blood lymphocytosis, or patients presenting with clinical symptoms, who are suspected of having a malignant B or T lymphoproliferative disorder. Testing is performed on blood if there are abnormal circulating cells or bone marrow otherwise. The aim is to demonstrate a monoclonal population and classify the underlying lymphoproliferative disorder. The lymphoproliferative workup consists of a detailed morphology report, membrane immunofluorescence and surface membrane immunoglobulins. All of which are essential in establishing a diagnosis.

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Indications

Unexplained lymphocytosis or if patient presents with symptoms suggestive of a lymphoproliferative disorder.

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Sample Type

Whole Blood/Bone marrow ( EDTA 4.0 ML ), Date and time of collection to be written on sample.

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Reference Range

N/A

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Turnaround Time

A verbal interim result is usually available within 24 hours of sample receipt if the lab is contacted in advance and a contact name and number is given. 5 working days for validated report.

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Testing Frequency

Daily (Monday - Friday) No out of hours or weekend service provided Sample should ideally be received by lab within 24 hours of collection. External samples should be sent by 1ST class post according to postal regulations for transporting samples or local transport arrangements if in place.

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External Notes

Store sample at room temperature if not sending immediately to lab. No out of hours or weekend service provided for this investigation. Relevant clinical information should be provided on request form.

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References

1. WHO Classification of tumours: Pathology and Genetics of Tumours of Haemopioetic and Lymphoid tissues. 4th Edition. Edited by Elaine S Jaffe et al (IARC Press Lyon 2008)

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Please note: the above information is subject to change and we endeavour to keep this website up to date wherever necessary.