Centromere Antibody, IIF, Kinetechore

Immunology

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Description

Anti-centromere antibody is a marker for the CREST variant of scleroderma. Positive centromere antibodies are also found in primary biliary cirrhosis, of whom half may have features of scleroderma (progressive systematic sclerosis) and in other conditions such as primary Raynaud's. Up to five different centromeric antigens, CENP A-E have been recognised.

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Indications

Scleroderma, CREST, Raynaud's, PBC.

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Sample Type

2mL Serum (Gel 5mL Yellow tube).
Requests from outside Sheffield: transport at ambient temperature via Royal Mail or Courier.

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Reference Range

Normal result = Negative

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Turnaround Time

Within 5 days

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Testing Frequency

Daily

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References

Koenig M, Diede M, Senecal JL. Predictive value of antinuclear autoantibodies:the lessons of the systemic sclerosis autoantibodies. Autoimmunity reviews. 2008. 7: 588-593.
Muro Y. Antinuclear antibodies. Autoimmunity. 2005. 38(1): 3-9.
Gonzalez-Buitrago JM, Gonzalez C, Hernando M et al. Antibodies to centromere antigens measured by an automated enzyme immunoassay. Clinica Chimica Acta. 2003. 135-138.
Kavanagh A, Tomar R, Reveille J et al. Guidelines for clinical use of antinuclear antibody test and tests for specific autoantibodies to nuclear antigens. American College of Pathologists. Arch Pathol Lab Med. 2000. 124(1): 71-81.
Powell F C et al. The centromere antibody in patients with progressive systemic sclerosis. Arthritis Rheum. 1984. 27:125-131.

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See Also

Anti Nuclear Antibodies.

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