Disseminated Intravascular Coagulation (DIC) Screen

Coagulation

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Description

Disseminated Intravascular Coagulopathy (DIC) was defined by the DIC Subcommittee of the Scientific and Standardization Committee of the International Society of Haemostasis and Throbosis in 2001 as an acquired syndrome characterized by the intravascular activation of coagulation with the loss of localization arising from different causes. It can originate from and cause damage to the microvasculature, which, if sufficiently severe, can produce organ dysfunction. Conditions triggering DIC include sepsis, trauma (inc burns), particularly head and polytrauma, obstetric complications, malignancy, toxins (snake venom), immunologic/allergic disorders, vascular disorders (eg.aneurysm).

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Indications

Investigation and diagnosis of possible Disseminated Intravascular Coagulopathy ( DIC ).

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Sample Type

Plasma ( Citrate Blue ) x 1

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Reference Range

Reference ranges for all individual tests indicated on report

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Turnaround Time

Within 1 hour

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Testing Frequency

Daily / continuous processing 24 hours

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External Notes

The accuracy of all coagulation tests is greatly influenced by pre analytical variables. It is essential that sample quality is given the highest of priorities. Samples which fail to meet quality criteria including age of sample, specimen fill ( >90% ), haemolysed, clotted or activated samples will be rejected and a repeat sample requested.Screen includes Prothrombin time, Activated Partial Thromboplastin Time, Fibrinogen and D-Dimer

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References

1.CLSI. Collection, Transport and Processing of Blood Specimensfor Testing Plasma-based Coagulation Assays and Molecular Haemostasis Assays. Approved Guideline - Fifth Edition. CLSI document H21-a5 [ISBN 1-56238-657-3]. CLSI, 940 West Valley Rd., Suite 1400 Wayne, Pennsylvania 19087-1898 USA, 2008
2. Guidelines for the diagnosis and management of disseminatedintravascular coagulation 2009 Blackwell Publishing Ltd, British Journal of Haematology, 145, 24-33
3. Guidelines for the diagnosis and management of disseminated intravascular coagulation M Levi1, C. H. Toh, J Thachil and H. G. WatsonArticle first published online: 13 FEB 2009 DOI: 10.1111/j.1365-2141.2009.07600.x 2009 Blackwell Publishing Ltd
4.The withdrawal of Activated Protein C from the use in patients with severe sepsis and DIC [Amendment to the BCSH guideline on disseminated intravascular coagulation].Thachil J, Toh CH, Levi M, Watson HG.Br J Haematol. 2012 May;157( 4 ):493-4. doi: 10.1111/j.1365-2141.2011.09019.x. Epub 2012 Jan 9.

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See Also

Activated Partial Thrmboplastin Time ( APTT )
Prothrombin Time ( PT )
D-Dimer
Clotting Screen

Please note: the above information is subject to change and we endeavour to keep this website up to date wherever necessary.