Endothelial Cell Antibodies

Immunology

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Description

Endothelial cell antibodies are directed against various antigens on the surface of endothelial cells. They have various pathophysiological effects on endothelial cells, include increased leukocyte adhesiveness, cytotoxicity, induction of apoptosis and activation of coagulation and thrombosis [1]. These autoantibodies have been seen in some cases of immune vasculitic diseases, including Wegener's granulomatosis and Kawasaki's disease, and also with SLE and anti-phospholipid syndrome (APS) [2,3]. Endothelial cell antibodies have also been shown to occur in healthy individuals [1].

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Indications

Vasculitic disease, SLE and Rheumatoid arthritis.

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Sample Type

2mL Serum (Gel 5mL Yellow tube).
Requests from outside Sheffield: transport at ambient temperature via Royal Mail or Courier.

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Reference Range

Normal result is Negative.

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Turnaround Time

Within 10 days

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Testing Frequency

As required

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References

Servettaz A, et al. Natural anti-endothelial cell antibodies. Autoimmunity Rev. 2008. 7:426-430. [Ref 1]
PRU Handbook of Autoimmunity. 4th Edition. 2007. [Ref 2]
Farsi A, et al. Activation of the immune system and coronary artery disease: the role of anti-endothelial cell antibodies. Atherosclerosis. 2001. 154(2):429-436 [Ref 3]

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Please note: the above information is subject to change and we endeavour to keep this website up to date wherever necessary.