Endocrine Antibodies (Adrenal, Ovarian, Testes)

Immunology

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Description

Cytochrome P450 enzymes involved in steroid biosynthesis are the targets of autoimmune attack against steroid producing cells. These include 17 alpha-hydroxylase ( P450c17 ), 21 alpha-hydroxylase ( P450c21 ) and cholesterol desmolase ( P450scc ) enzyme. Antibodies that stain more than one tissue react with enzymes common to the hormonal synthetic pathways in these tissues and are generally termed steroid cell antibodies. Antibodies to these enzymes can be associated with autoimmune Addison's disease where a gradual destruction of the adrenal gland leads to adrenocortical insufficiency. It is a chronic disorder with a long pre-clinical period and in the majority of cases there are adrenal cortex antibodies present. The presence of these antibodies can predict the risk of progression to adrenal failure. Steroid cell antibodies can also be associated with premature ovarian failure and premature testicular failure. They are also associated with the autoimmune polyglandular syndrome types 1,2 and 3. Autoimmune endocrinopathy may be seronegative in a minority of cases.

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Indications

Autoimmune Addison's disease, autoimmune gonadal failure, polyglandular autoimmunity.

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Sample Type

2mL Serum ( Gel 5mL Yellow tube ). Requests from outside Sheffield: Transport at ambient temperature via Royal Mail or Courier.

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Reference Range

Normal result = Negative

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Turnaround Time

Within 10 days

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Testing Frequency

Weekly

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References

Kahaly G. Polyglandular autoimmune syndromes. Eur. J. Endocrinol. 2009. 161:11-20.
Anderson MS. Update in endocrine autoimmunity. J. Clin.Endocrinol. Metab. 2008. 93( 10 ):3663-3670.
Coco G, et al. Estimated risk for developing autoimmune Addison's disease in patients with adrenal cortex antibodies. J. Clin. Endocrinol. Metab. 2006. 91:1637-1645.
Betterle C, Coco G, Zanchetta R. Adrenal cortex autoantibodies in subjects with normal adrenal function. Best Prcatice and Reseacrh Clinical Endocrinology and Metabolism. 2005. 19( 1 ):85-99.
Soderbergh A, et al. Prevalence and Clinical Associations of 10 Defined Autoantibodies in Autoimmune Polyendocrine Syndrome Type I. J.Clin.Endocrinol.Metab. 2004. 89:557-562.
Betterle C, et al. Autoimmune Adrenal Insufficiency and Autoimmune Polyendocrine Syndromes: Autoantibodies, Autoantigens, and Their Applicability in Diagnosis and Disease Prediction. Endocrine Reviews. 2002. 23( 3 ):327-364.

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See Also

Adrenal antibodies

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