Urine Gluten Immunogenic Peptides

Immunology

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Description

Compliance with a gluten free diet (GFD) is the only treatment option available for Coeliac disease. However maintaining compliance can be difficult and 'hidden' gluten may be ingested. This can lead to on going symptoms of the disease and histological findings typical of coeliac disease on duodenal biopsy. Refractory coeliac disease is defined by persistent symptoms and signs of malabsorption despite gluten exclusion for more than 12 months [1]. This test may aid in determining if the symptoms are due to the presence of trace amounts of dietary gluten or refractory coeliac disease which requires different management. Gluten Immunogenic Peptides are resistant to gastrointestinal digestion and the absence of these peptides in urine has been shown to correspond with GFD compliance [1]. This can provide a non-invasive way of assessing if symptoms that a patient may be experiencing are due to the presence of gluten in the diet. The test is likely to provide a negative result approximately 24 hours after gluten was last ingested. A positive result will usually be seen within hours of gluten being eaten.

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Indications

Patients with coeliac disease and on going symptoms despite following a gluten free diet.

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Sample Type

10mL Urine (no preservative). Requests from outside Sheffield: Transport at ambient temperature via Royal Mail or Courier.

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Reference Range

Negative = Compliant with gluten free diet.
Positive = The diet contains gluten.

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Turnaround Time

Within 5 days

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Testing Frequency

Weekly

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References

De Lourdes Moreno M, Cebolla A, Munoz-Suano A. Detection of gluten immunogenic peptides in the urine of patients with Coeliac disease reveals transgressions in the gluten-free diet and incomplete mucosal healing. GUT. 2017. 66;250-257. [Ref 1].
Syage JA, Kelly CP, DIckason MA. et al. Determination of gluten consumption in coeliac disease patients on a gluten-free diet. Am J Clin Nutr. 2018. 107;201-207.
Freeman HJ. Dietary compliance in coeliac disease. World J Gastroenterol. 2017. 23(15);2635-2639.

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Please note: the above information is subject to change and we endeavour to keep this website up to date wherever necessary.