ADAMTS-13 Activity Assay
Coagulation
Description
ADAMTS-13 (a disintegrin-like and metalloproteinase with thrombospondin type 1 motif 13) is an enzyme (vWF-cleaving protease) that specifically cleaves unusually large vWF multimers (ULvWF) which induce platelet thrombus formation under high shear stress. If the activity is lowered, ULvWF may accumulate within the blood causing thrombosis due to platelet aggregation, which in turn may lead to Thrombotic Thrombocytopenic Purpura (TTP).
Sample Type
Plasma (Citrate 2.7ml Blue) x 2
Reference Range
52-149 IU/dL
Turnaround Time
Within 1 day
Testing Frequency
On demand
External Notes
See ADAMTS-13 Activity and Antibody Assays Referral form
Patient Preparation
Preparation No special requirements.
References
Hubbard AR et al. Establishment of the WHO 1st International Standard ADAMTS13, plasma (12/252): communication from the SSC of the ISTH. J Thromb Haemost. 2015 Jun;13(6):1151-3.
See Also
ADAMTS-13 ANTIBODY ASSAY
Please note: the above information is subject to change and we endeavour to keep this website up to date wherever necessary.
Your contact for this test
Rebekah Fretwell BSc (Hons) Medicine and Pharmacology, MSc Pathology
Senior Biomedical Scientist and ADAMTS-13 Section Lead - Coagulation
You are enquiring about
ADAMTS-13 Activity Assay