High sensitivity Troponin T

Clinical Chemistry

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Description

The Fourth Universal Definition of Myocardial Infarction (2018) gives the following definition:

Detection of a rise and/or fall of cardiac troponin values with at least one value above the 99th percentile (14 ng/L for the Roche hsTnT assay) of the upper reference limit (URL) and at least one of the following:

a) Symptoms of myocardial ischaemia
b) New ischaemic ECG changes
c) Development of pathological Q waves
d) Imaging evidence of new loss of viable myocardium or new regional wall motion abnormality in a pattern consistent with an ischaemic aetiology
e) Identification of a coronary thrombus by angiography or autopsy (not for types 2 or 3 MIs)

Troponin results must be interpreted in the clinical context. Other causes of increased hsTnT include cardiac trauma, heart failure, renal failure, cardiomyopathy, sepsis, diabetes, pulmonary embolism, and drug-induced cardiotoxicity.

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Indications

Investigation of chest pain or possible myocardial damage of any cause.

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Sample Type

Serum, SST/Gel. Minimum 2 mL (1 mL separated serum)

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Reference Range

Reference ranges are provided on the report. Alternatively, please contact the laboratory for current ranges.

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Turnaround Time

Within 2 hours (final report within 48 hours)

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Testing Frequency

On demand

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External Notes

The new universal definition of myocardial infarction (UDMI) recommends that the decision limit for myocardial injury corresponds to the 99th percentile of a normal reference population. For the new Roche high sensitivity troponin T assay, the 99th percentile is 14 ng/L. The assay also meets the UDMI requirement that the coefficient of variation at the 99th percentile is 10% or less.

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Please note: the above information is subject to change and we endeavour to keep this website up to date wherever necessary.