High sensitivity Troponin T

Clinical Chemistry


Description

The Fourth Universal Definition of Myocardial Infarction (2018) gives the following definition:

Detection of a rise and/or fall of cardiac troponin values with at least one value above the 99th percentile (14 ng/L for the Roche hsTnT assay) of the upper reference limit (URL) and at least one of the following:

a) Symptoms of myocardial ischaemia
b) New ischaemic ECG changes
c) Development of pathological Q waves
d) Imaging evidence of new loss of viable myocardium or new regional wall motion abnormality in a pattern consistent with an ischaemic aetiology
e) Identification of a coronary thrombus by angiography or autopsy (not for types 2 or 3 MIs)

Troponin results must be interpreted in the clinical context. Other causes of increased hsTnT include cardiac trauma, heart failure, renal failure, cardiomyopathy, sepsis, diabetes, pulmonary embolism, and drug-induced cardiotoxicity.


Indications

Investigation of chest pain or possible myocardial damage of any cause.


Sample Type

Serum, SST/Gel. Minimum 2 mL (1 mL separated serum)


Reference Range

Reference ranges are provided on the report. Alternatively, please contact the laboratory for current ranges.


Turnaround Time

Within 2 hours (final report within 48 hours)


Testing Frequency

On demand


External Notes

The new universal definition of myocardial infarction (UDMI) recommends that the decision limit for myocardial injury corresponds to the 99th percentile of a normal reference population. For the new Roche high sensitivity troponin T assay, the 99th percentile is 14 ng/L. The assay also meets the UDMI requirement that the coefficient of variation at the 99th percentile is 10% or less.


Please note: the above information is subject to change and we endeavour to keep this website up to date wherever necessary.

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High sensitivity Troponin T