Human Chorionic Gonadotrophin / LDH

Immunology

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Description

The main application of all tumour markers is monitoring for relapse or progression. Use as a diagnostic aid requires care and knowledge of the test limitations. Opportunistic screening is discouraged. Beta hCG in association with AFP, PLAP and LDH is of value in the diagnosis of gonadal and extragonadal germ cell tumours [1,2]. Raised levels are seen in 75% of teratomatous and combined tumours, and 30% of seminomas and dysgerminomas. Concentrations of beta hCG >100,000 IU/L indicate a poorer prognosis [1]. Beta hCG may also be slightly elevated in acute epididymo-orchitis and in cases of hydrocele [1].

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Indications

Gonadal and extragonadal germ cell tumours.

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Sample Type

2mL Serum (Gel 5mL Yellow tube). Requests from outside Sheffield: Transport at ambient temperature via Royal Mail or Courier.

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Reference Range

See report.

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Turnaround Time

Within 5 days

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Testing Frequency

Daily (send away test).

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External Notes

Test performed in Clinical Chemistry.

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References

PRU Handook of Clinical Immunochemistry. 9th Edition. 2007. [Ref 1]Schmoll HJ. Extragonadal germ cell tumours. Eur Soc Med Oncology. 2002. 13(sup 4):265-272. [Ref 2]

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