IA2 Antibodies, Anti Tyrosine Phosphatase Antibodies

Immunology

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Description

Type 1 diabetes is the result of T-cell mediated destruction of the beta cells in the pancreas. There are several antibodies that may be present such as GAD65 antibodies, islet cell antibodies and islet tyrosine phosphatase 2 (IA2) antibodies [2]. These antibodies can be used to predict the onset of diabetes mellitus [2]. In the assessment of first degree relatives for autoimmune diabetes, positive results in more than one of the marker antibodies (GAD, Islet cell, IA2 or insulin) can be associated with the onset of autoimmune diabetes [2]. IA2 antibodies have been shown to be a better marker of glycemic control and of a lower insulin requirement, indicating residual beta-cell function [3].

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Indications

Autoimmune Diabetes Mellitus.

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Sample Type

2mL Serum (Gel 5mL yellow tube). Requests from outside Sheffield: Transport at ambient temperature via Royal Mail or Courier.

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Reference Range

Negative result < 10 IU/mL.Reference range established by manufacturer and verified in-house.

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Turnaround Time

Within 10 days

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Testing Frequency

Alternate weeks

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References

Nice guideline 15. Type 1 diabetes: diagnosis of type 1 diabetes in adults. 2004.Pihoker C, et al. Autoantibodies in diabetes. Diabetes. 2005. 54(Suppl 2):S52-S61. [Ref 2]Zanone MM, et al. Glutamic acid decarboxylase and ICA512/IA-2 autoantibodies as disease markers and relationship to residual beta-cell function and glycaemic control in young type 1 diabetic patients. Metabolism. 2003. 52:25-29. [Ref 3]Batstra MR, Aanstoot HJ, Herbrink P. Prediction and diagnosis of type 1 diabetes using beta-cell autoantibodies. Clin. Lab. 2001. 47:497-501. [Ref 2]

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See Also

Islet Cell Antibodies.
GAD Antibodies.
Insulin Antibodies.

Please note: the above information is subject to change and we endeavour to keep this website up to date wherever necessary.