Interleukin 6 (IL-6)

Immunology

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Description

IL-6 is a pleiotropic cytokine involved in both the initiation and the maintenance of inflammatory and immunological responses [3,4]. It is produced by various cells including monocytes and neutrophils [1,3] and plays a key role in lymphocyte development and function [2,4]. IL-6 has been shown to be actively involved in rheumatoid arthritis, systemic onset idiopathic arthritis, and inflammatory bowl diseases including Crohn's disease [1,2,4]. Patients with conditions that have underlying low level inflammation, including diabetes and obesity may also display raised IL-6 levels, however IL-6 concentration has been shown to increase with age [2]. It has been speculated that increased levels of IL-6 and CRP may be an indicator of cardiac events [4].

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Indications

Inflammatory reactions.

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Sample Type

2mL Serum (Gel 5mL Yellow tube) or 2mL Lithium Heparin or 2mL Plasma (EDTA). Requests from outside Sheffield: Transport at ambient temperature via Royal Mail or Courier.

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Reference Range

<7 pg/mL.Reference ranges established by manufacturer with

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Turnaround Time

Within 4 weeks

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Testing Frequency

Discuss with Immunology prior to requesting this test.

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References

Fonseca JE, et al. Interleukin-6 as a key player in systemic inflammation and joint destruction. Autoimmunity Rev. 2009. 8:538-542. [Ref 1]Naugler WE, Karin M. The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer. Trends in Molecular Medicine. 2007. 474:1-11. [Ref 2]Maggio M, et al. Interleukin-6 in aging and chronic disease: a magnificent pathway. J Gerontol Biol Sci Med Sci. 2006. 61:575-584. [Ref 3]Lipsky PE. Interleukin-6 and rheumatic diseases. Arthritis Research and Therapy. 2006. 8(2):S4-8. [Ref 4]

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Please note: the above information is subject to change and we endeavour to keep this website up to date wherever necessary.