inv (16)
Molecular Haematology
Description
The pericentric inversion of chromosome 16 is closely associated with AML-M4Eobeing found in virtually all cases. It is also found in 10% M4 without eosinophilia. It is associated with a good prognosis. The molecular consequence of an inv( 16 ) is a CBFB-MYH11gene fusion. Approximately 30% of cases are due to a t( 16;16 ) which has the same molecular consequence as the inversion. This fusion gene can be detected in cases of AML lacking inv( 16 ) by classical cytogenetics. There are various different fusion forms ( A,B,C,D,E,F,G,H ) which are detectable by RT-PCR.
Indications
Used to monitor cases known to have inv( 16 ).
Sample Type
5ml EDTA blood or bone marrow, less than 48 hrs old
Turnaround Time
Within 4 weeks
Testing Frequency
As required
External Notes
�Level of detection 1 leukaemic cell:103 normal cells
Please note: the above information is subject to change and we endeavour to keep this website up to date wherever necessary.
Your contact for this test
You are enquiring about
inv (16)