Lactate Dehydrogenase (LDH)

Clinical Chemistry

Description

The lactate dehydrogenase ( LDH ) enzyme is widely distributed in tissue, particularly in the heart, liver, muscles and kidneys. The LDH in serum can be separated into five different isoenzymes. Each isoenzyme is a tetramer composed of two different subunits. These two subunits have been designated heart and muscle, based on their polypeptide chains. There are two homotetramers, LDH-1 ( heart ) and LDH-5 ( muscle ), and three hybrid isoenzymes. LDH is elevated in haemolysed samples, hepatitis, rhabdomyolysis, leukaemia, megaloblastic anaemias, malignant diseases, myocardial infarction and haemolytic anaemia.

Indications

ï¿½ General indicator of acute or chronic tissue damage ï¿½ Monitoring of various primary CNS tumours or haematological malignancies ï¿½ Diagnosis, prognosis and monitoring of germ cell tumours ï¿½ Identifying haemolytic anaemia ï¿½ Prognostic indicator in Small Cell Lung Carcinoma ( SCLC )

Sample Type

Serum, SST/Gel, 2 mL ( 1 mL separated serum ). Avoid haemolysis

Reference Range

Reference ranges are provided on the report. Alternatively, please contact the laboratory for current ranges.

Turnaround Time

Within 1 day

Testing Frequency

Daily

External Notes

Plasma may be contaminated with platelets which contain high concentrations of lactate dehydrogenase and should be avoided ( Roche information ).

Please note: the above information is subject to change and we endeavour to keep this website up to date wherever necessary.

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Lactate Dehydrogenase (LDH)