t( 8;21 )

Molecular Haematology

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Description

The chromosomal translocation t( 8;21 ) has been shown to be important in clinical practice and can identify a subgroup of AML with relatively good prognosis. It is found in approximately 20% of AML-M2, and responds well to treatment with cytosine arabinoside. It is suggested that patients with this translocation do not benefit from bone marrow transplantation.The molecular consequence of a t( 8;21 ) is an AML-ETO gene fusion. This fusion gene can be detected in cases of AML lacking t( 8;21 ) by classical cytogenetics. The breakpoints in t( 8;21 ) are highly conserved, so can be detected by RT-PCR.

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Indications

Used to monitor cases known to have t( 8;21 ).

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Sample Type

5ml EDTA blood or bone marrow, less than 48 hrs old.

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Turnaround Time

Within 4 weeks

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Testing Frequency

As required.

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External Notes

Level of detection 1 leukaemic cell in 105 normal cells.

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