Muscle Specific Kinase Antibodies

Immunology

---

Description

MuSK antibodies are involved in the pathogenesis of acetylcholine receptor antibody negative myasthenia gravis, this is more common in adults than children. MuSK antibodies have been shown to be present in 35-70% of adult Myasthenia patients that have negative acetylcholine receptor antibodies (ACR antibodies) [1].

---

Indications

Myasthenia Gravis in ACR negative patients.

---

Sample Type

2mL Serum (Gel 5mL Yellow tube). Samples must be urgently transported to the laboratory. Requests from outside Sheffield: Please discuss transport requirements prior to requesting this test.

---

Reference Range

Normal is Negative.

---

Turnaround Time

Within 6 weeks

---

Testing Frequency

15 days (send away test)

---

References

Anlar B, Imaz VY, Saruhan-Direskeneli G. Long remission in muscle specific kinase antibody positive juvenile myasthenia. Paediatric Neurology. 2009. 40(6):455-456. [Ref 1]
Vincent A, Leite MI. Neuromuscular junction autoimmune disease: muscle specific kinase antibodies and treatments for myasthenia gravis. Current Opinions in Neurology. 2005. 18(5):519-525

---

See Also

Acetylcholine receptor antibodies

Please note: the above information is subject to change and we endeavour to keep this website up to date wherever necessary.