N-Methyl-D-Aspartate Receptor Antibodies ( NMDAR )

Immunology

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Description

In women younger than 45 years, a form of encephalitis associated with ovarian teratoma and presenting with seizures and psychiatric symptoms has been described. Most patients have antibodies to NR1/NR2 heteromers of the N-methyl-D-aspartate receptor (NMDAR) [1].

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Indications

Cerebral dysfunction. Paraneoplastic encephalitis associated with immature teratoma of the ovary.

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Sample Type

2mL Serum (Gel 5mL Yellow tube) or 250uL CSF. Requests from outside Sheffield: Transport at ambient temperature via Royal Mail or Courier.

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Reference Range

Negative = Normal.

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Turnaround Time

Within 10 days

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Testing Frequency

Weekly

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References

Wang W, et al. Neural cell cycle dysregulation and central nervous system diseases. Progress in Neurobiology. 2009. 89(1):1-17.
Neihusmann P, et al. Diagnostic value of N-methyl-D-aspartate antibodies in women with new-onset epilepsy. Archives of Neurology. 2009. 66(4):458-464. [Ref 1]

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