Transferrin

Immunology

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Description

Transferrin is a beta-glycoprotein which specifically binds to two atoms of free iron and serves as the transport protein for this essential element. In the normal individual the percentage saturation of transferrin with iron is in the order of 35% [1]. The major use of tranferrin measurement is in the demonstration of increased concentrations in iron deficiency anaemia. In this context consideration should also be given to the assay of serum ferritin [1,2]. Elevations of transferrin are also seen in the second and third trimesters of pregnancy, and during exogenous oestrogen administration. Decreased concentrations are seen in chronic infection neoplasia, hepatic and renal disease. Except in the case of severe liver disease, the serum transferrin concentration is inversely proportional to the total body iron store. Transferrin is also decreased in acute tissue injury when it acts as a negative acute phase reactant [1]. Atransferrinaemia is a rare congenital disorder that is associated with hypochromic anaemia with iron overload [3].

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Indications

Investigation of iron deficiency anaemia. Renal Tubular Dysfunction.

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Sample Type

2mL Serum (Gel 5mL Yellow tube). Requests from outside Sheffield: Transport at ambient temperature via Royal Mail or Courier.

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Reference Range

2.0 - 3.2 g/L.

Reference range established in house with PRU collaboration.

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Turnaround Time

Within 10 days

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Testing Frequency

As required

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References

PRU Handbook of Clinical Immunochemistry. 9th Edition. 2007.Cook JD. Diagnosis and management of iron-deficiency anaemia. 2005. Best Pract Res Clin Haematol. 18(2):319-332. [Ref 2]Worwood M. Inherited iron loading: genetic testing in diagnosis and management. 2005. Blood Rev. 19(2):69-88. [Ref 3]

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Please note: the above information is subject to change and we endeavour to keep this website up to date wherever necessary.