Prolactin

Clinical Chemistry

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Description

Human prolactin (hPRL) is a single chain polypeptide of 199 amino acids and a molecular weight of approximately 23,000 daltons. Prolactin is produced by the anterior pituitary gland and one of the main factors regulating secretion is dopamine transported from the hypothalamus in the portal vessels. Interruption of this blood supply by pituitary stalk lesions and drugs affecting dopaminergic receptors can have profound effects on circulating prolactin concentrations. Prolactin appears in the blood promptly after administration of thyrotrophin-releasing hormone (TRH). The major physiologic action of prolactin is the initiation and maintenance of lactation in women.

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Indications

Known or suspected pituitary disease. Unexpected galactorrhoea. Menstrual disturbances.

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Sample Type

Serum, SST/Gel, minimum 2mL (1mL separated serum)

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Reference Range

Reference ranges are provided on the report. Alternatively, please contact the laboratory for current ranges.

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Turnaround Time

Within 3 days

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Testing Frequency

Daily

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