ADAMTS-13 Antibody Assay

Coagulation

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Description

ADAMTS-13 (a disintegrin-like and metalloproteinase with thrombospondin type 1 motif 13) is an enzyme (vWF-cleaving protease) that specifically cleaves unusually large vWF multimers (ULvWF) which induce platelet thrombus formation under high shear stress. If the activity is lowered, ULvWF may accumulate within the blood causing thrombosis due to platelet aggregation, which in turn may lead to Thrombotic Thrombocytopenic Purpura (TTP).

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Sample Type

Plasma (Citrate 2.7ml Blue) x 2

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Reference Range

Negative samples: <12 U/mlBorderline samples: 12-15 U/mlPositive samples >15 U/ml

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Turnaround Time

Within 1 day

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Testing Frequency

On demand

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External Notes

See ADAMTS-13 Activity and Antibody Assays Referral form

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Patient Preparation

No special requirements

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Please note: the above information is subject to change and we endeavour to keep this website up to date wherever necessary.