Salivary Duct Antibody and Salivary Gland Antibody
Immunology
Description
Antibodies against the cytoplasm of the salivary duct cells are seen in Sjogren's syndrome and also in rheumatoid arthritis, SLE and myasthenia gravis [1]. They are usually IgG class although IgM antibodies may be detected at approximately half the frequencey of IgG antibodies. IgA antibodies to salivary duct are rarely seen [1]. Salivary duct antibodies are seen in approximately 50% of individuals with Sjogren's syndrome [1]. The most common autoantibodies in primary Sjorgren's syndrome are those that target the Ro/La RNP complex and these are included in the European-American diagnostic criteria for primary Sjogren's syndrome [2,3].
Indications
Sjogrens syndrome.
Sample Type
2mL Serum (Gel 5mL Yellow tube). Requests from outside Sheffield: Transport at ambient temperature via Royal Mail or Courier.
Reference Range
Normal result = NEGATIVE.
Turnaround Time
Within 10 days
Testing Frequency
As required
References
Routsias JG, Tzioufas AG. Sjogren's syndrome - study of autoantigens and autoantibodies. Clinical Reviews in Allergy and Immunology. 2007. 32(3):238-251 [Ref 2]Vitali C, et al. European Study Group on Classification Criteria for Sj�gren's Syndrome. Classification criteria for Sj�gren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis. 2002. 61(6):554-558. [Ref 3]Gordon TP, et al. Autoantibodies in primary Sjogren's syndrome: new insights into mechanisms of autoantibody diversification and disease pathogenesis. Autoimmunity. 2001. 34(2):123-132.Feltkamp TEW, Rossum AL. Antibodies to salivary duct cells, and other autoantibodies in Sjogren's syndrome and other idiopathic autoimmune diseases. Clin Exp Immunol. 1968. 3(1):1-16. [Ref 1]Macsween RNM, Goudie RB, Anderson JR et al. Occurrence of antibody to salivary duct epithelium in Sjogrens disease, rheumatoid arthritis and other arthritides. A clinical and laboratory study. Ann. Rheum. Dis. 1967. 26:402.
See Also
Anti nuclear antibodies (ANA); Anti-mitochondrial antibodies (AMA); ENA types
Please note: the above information is subject to change and we endeavour to keep this website up to date wherever necessary.
Your contact for this test
Clare Del-Duca BSc (Hons) Biomedical Science, MSc Pathological Science
Laboratory Manager - Immunology and Protein Reference Unit
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Salivary Duct Antibody and Salivary Gland Antibody