Sex Hormone Binding Globulin (SHBG)

Clinical Chemistry

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Description

Sex hormone-binding globulin ( SHBG ) is a glycoprotein, synthesised in the liver, which binds testosterone and 5a-dihydrotestosterone with high affinity, and oestradiol with somewhat lower affinity. It has a single steroid hormone-binding site, a molecular mass of approximately 80,000 to 100,000 daltons, and consists of two subunits, roughly equal in size. Serum concentrations are affected by many drugs including oral contraceptives. SHBG concentration rises slowly with age and is elevated in hyperthyroidism, hypogonadism, anorexia nervosa, pregnancy, cirrhosis and other excess oestrogen states. Levels are reduced in hypothyroidism, hyperandrogenism, obesity, hirsutism and polycystic ovary disease.

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Indications

Investigation of hyperandrogenism in females and of low testosterone in males.

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Sample Type

Serum, SST/Gel, minimum 2 mL ( 1 mL separated serum )

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Reference Range

Reference ranges are provided on the report. Alternatively, please contact the laboratory for current ranges.

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Turnaround Time

Within 3 days

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Testing Frequency

As required

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