Lymphocyte Subsets (HIV Immune Monitoring)

Haematology

---

Description

Subset analysis ( primarily the CD4 count ) is important in HIV infected individuals, to monitor disease progression and effectiveness of treatment. Lymphocyte subset analysis is also carried out on various patient groups to determine the absolute number of T helper, T suppressor, B and NK lymphocytes present. Lymphocyte subsets are performed on patients presenting with an unexplained lymphocytosis to establish the nature of the proliferation and to help distinguish reactive changes from malignant disease.

---

Indications

Lymphocyte subsets indicated for CD4 count monitoring in HIV patients, patients on rituximab therapy for CD19 B cell counts, or for other monitoring purposes, such as immune deficiencies, post allogeneic stem cell transplant, or infectious diseases where appropriate 

---

Sample Type

(EDTA 4.0ml Lavender) Date and time of collection to be written on sample

---

Reference Range

(Cells/ul)
CD3: 0.75 - 2.51
CD3/4: 0.43 - 1.69
CD3/8: 0.22 - 1.21
CDCD16/56: 0.12 - 0.60
CD19: 0.12 - 0.64

---

Turnaround Time

Within 3 working days, unless required urgently then please contact Lab

---

Testing Frequency

Daily (Monday - Friday) No out of hours or weekend service provided External samples should be sent by 1ST class post according to postal regulations for transporting samples or local transport arrangements if in place.

---

External Notes

Samples to be sent to laboratory before 3pm. Stipulate time sample taken. ( re/diurnal variation ). Sample must NOT have been refrigerated. No out of hours or weekend service provided for this investigation.

---

References

Guidelines for the enumeration of CD4+ T lymphocytes in immunosuppressed individuals: General Haematology Task Force of BCSH. Clinical Laboratory Haematology. ( 1997 ) Vol 19 p 231- 241.

---

Please note: the above information is subject to change and we endeavour to keep this website up to date wherever necessary.