Thrombophilia and Lupus Screen

Coagulation

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Description

Thrombophilia testing aims to detect an increased tendency to venous thrombosis if patient selection and testing is in accordance with published guidelines. Lupus anticoagulant activity may be seen in patients with primary and secondary antiphospholipid syndrome. These antibodies, paradoxically,prolong clotting times in vitro (usually APTT but occasionally PT),but in vivo are associated with thrombosis.

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Indications

Where a heritable thrombophilia screen is indicated according to appropriate guidelines. Please request lupus anticoagulant screening separately if indicated.

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Sample Type

Plasma ( Citrate Blue ) x 5 and 1 serum sample.

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Reference Range

Reference range is indicated on the report

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Turnaround Time

Within 2 weeks

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Testing Frequency

Weekly.

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External Notes

Direct oral anticoagulants (such as Rivaroxaban and Dabigatran) can interfere with certain assays; PLEASE SPECIFY IF THE PATIENT IS ON ANTICOAGULANTS.

Liver disease, DIC, warfarin, vitamin K deficiency may also affect results.

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Patient Preparation

No special requirements.

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References

Baglin et al; British Committee for Standards in Haematology. Clinical guidelines for testing for heritable thrombophilia. Br J Haematol. 2010 Apr;149( 2 ):209-220.
Keeling D. Guidelines on the investigation and management of antiphospholipid syndrome. Br J Haem, 2012, 157, 47-58.

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See Also

Anti-Cardiolipin Antibody
Lupus Anticoagulant Antibody Screen

Please note: the above information is subject to change and we endeavour to keep this website up to date wherever necessary.