Myelin Oligodendrocyte Glycoprotein Antibodies (MOG Antibodies)

Immunology

Description

Myelin Oligodendrocyte Glycoprotein ( MOG ) is a glycoprotein which is found on the outer membrane surface of the myelin sheath of nerve cells [1]. It is thought to act as a cellular adhesive molecule and regulate stability of the oligodendrocyte microtubules [2]. MOG antibodies cause demyelination of the nerves leading to neurological symptoms that does not meet the typical criteria for Multiple Sclerosis ( MS ). MOG antibody disease is similar in presentation to optic neuritis or transverse myelitis [1]. Patients presenting with symptoms of neuromyelitis optica but are seronegative for NMO antibodies may have MOG antibodies present [1,2,3]. MOG antibodies can also be associated with Acute Disseminated Encephalomyelitis ( ADEM ) which is more common in children [1]. The disease course can be monophasic or relapsing [2].

Indications

Neuromyelitis optica patients negative for NMO ( Aquaporin 4 ) antibodies. Reported in some children with Acute disseminated encephalomyelitis ( ADEM ) or Multiple sclerosis ( MS ).

Sample Type

2mL Serum ( Gel 5mL Yellow tube ). Requests from outside Sheffield: Transport at ambient temperature via Royal Mail or Courier.

Reference Range

Normal = Negative

Turnaround Time

Within 10 days

Testing Frequency

Weekly

References

Narayan R, Simpson A, Fritsche K, et al. MOG antibody disease: A review of MOG antibody seropositive neuromyeltis optica spectrum disorder. Mult Scler Relat Disord. 2018. 25: 66-72. [Ref 1].Wynford-Thomas R, Jacob A and Tomassini V. Neurological update: MOG antibody disease. Journal of Neurology. 2019. 266: 1280-1286. [Ref 2].Unguranu A, De Seze J, Ahle G, et al. Myelin oligodendrocyte glycoprotein antibodies in neuromyelitis optica spectrum disorder. Rev Neurol ( Paris ). 2018. 174: 675-679. [Ref 3].

Your contact for this test

Clare Del-Duca BSc (Hons) Biomedical Science, MSc Pathological Science

Laboratory Manager - Immunology and Protein Reference Unit

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Myelin Oligodendrocyte Glycoprotein Antibodies (MOG Antibodies)