Fibrinogen Antigen

Coagulation

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Description

The fibrinogen antigen test is used in the diagnosis of dysfibrinogenemia (fibrinogen with abnormal function). It is an immunoassay used for quantifying the amount of fibrinogen present in plasma, irrespective of its function.

When used in conjunction with a test of fibrinogen activity (i.e. Clauss fibrinogen) it allows for the differentiation between a quantitative deficiency of fibrinogen (both activity and antigen will show concordant low results) and a qualitative abnormality - dysfibrinogenemia (activity result reduced, antigen result will be in the reference range).  

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Indications

Low fibrinogen levels can be observed in the following clinical situations: acute liver failure, congenital afibrinogenemia or hypofibrinogenemia, disseminated intravascular coagulation, primary fibrinolysis, secondary fibrinolysis, treatment with thrombolytic drugs (streptokinase, urokinase, tissue plasminogen activator, L-Asparaginase)

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Sample Type

Plasma (Citrate 2.7ml Blue) x 1 or frozen (-80°C) citrated (0.109M) single spun platelet poor plasma, frozen in less than 6 hours from venepuncture.

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Reference Range

Current adult reference range indicated on the report.

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Turnaround Time

Within 14 days

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Testing Frequency

As required (usually batched), please contact the laboratory for urgent requests.

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External Notes

The accuracy of all coagulation tests is greatly influenced by pre analytical variables. It is essential that sample quality is given the highest of priorities. Samples which fail to meet quality criteria including age of sample, specimen fill (>90%), haemolysed, clotted or activated samples will be rejected and a repeat sample requested.

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Patient Preparation

No special requirements.

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References

Guidelines on the laboratory aspects of assays used in haemostasis and thrombosis. I. Mackie, P. Cooper, A. Lawrie, S. Kitchen, E. Gray, M. Laffan. International journal of laboratory haematology. Volume 35, Issue 1, pages 1-13, February 2013.
Guideline for the diagnosis and management of the rare coagulation disorders. Andrew D. Mumford et al. British Journal of Haematology, 2014, 167, 304-326.

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See Also

Clauss Fibrinogen
Derived Fibrinogen
Thrombin Time
Reptilase Time

Please note: the above information is subject to change and we endeavour to keep this website up to date wherever necessary.